The Substance 2024 Release.  — from there, an increasingly distraught elisabeth comes to learn of a mysterious black market drug known as the substance, which promises to deliver her a.  — as a smaller arthouse film, the substance's theatrical release begins on september 20, 2024.mubi distributes it after universal stepped away from its theatrical.

 — check out the new teaser trailer for the substance starring demi moore! Have you ever dreamt of a better version of yourself?